Title

Correlation between serum bile acids with severity of liver cirrhosis: A case-control study

Authors

Soham Doshi¹*, Pratibha Sonawane¹, Uditkumar Agrawal² & Ashfiyah Altafhusen Munshi³

Affiliation

¹Department of General Medicine, Government Medical College and Maharashtra Post Graduate Institute of Education And Research MUHS, Nashik, Maharashtra, India; ²Department of Biochemistry, NSC Government Medical College Khandwa, Madhya Pradesh, India; ³Department of Pathology, GMERS Medical College, Himmatnagar, Gujarat, India; *Corresponding author

Email

Soham Doshi - E-mail: dr.sohamdoshi@gmail.com
Pratibha Sonawane - E-mail: pratibhasonwane@gmail.com
Uditkumar Agrawal - E-mail: drudit786@gmail.com
Ashfiyah Altafhusen Munshi - E-mail: munshiashfiyah@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The association of serum bile acid levels with liver cirrhosis severity is of interest. Hence, 100 patients were admitted, among them 50 patients had variable severity of liver cirrhosis and 50 patients were controls. Serum bile acid levels were measured and their association was also analyzed with clinical parameters like Child-Pugh score, MELD score and liver function tests. The results indicate that serum bile acid concentrations are strongly associated with the severity of liver cirrhosis and potentially as a disease progression biomarker. Thus, the clinical value of bile acids as a marker for the severity of liver cirrhosis is shown.

Keywords

Serum bile acids, liver cirrhosis, child-pugh score, MELD score, biomarkers, liver function tests, disease progression

Citation

Doshi et al. Bioinformation 21(9): 3005-3009 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.