Title
A systematic review on the association of metabolic syndrome with telomere length and telomerase activity
Authors
Ipsita Dash1, Bibhu Prasad Behera2, Gaurav Gupta3, Om Padarabinda Dash4, Pratima Kumari Sahu1,*
Affiliation
1Department of Biochemistry, Sahed Rendo Majhi Medical College, Kalahandi, Odisha, India; 2Department of Internal Medicine, Saheed Rendo Majhi Medical College, Kalahandi, Odisha, India; 3Department of Pediatrics, All India Institute of Medical Sciences, Guwahati, Assam, India; 4Department of Pulmonary Medicine, Sahed Rendo Majhi Medical College, Kalahandi, Odisha, India; *Corresponding author
Ipsita Dash - E-mail:
ipsitadash71@gmail.com
Bibhu Prasad Behera - E-mail: drbibhu1111@yahoo.com
Gaurav Gupta - E-mail: drgaurav.amu@gmail.com Om
Padarabinda Dash - E-mail:
drompadarabindadash@gmail.com
Pratima Kumari Sahu - E-mail: sahoopratema@rediffmail.com
Article Type
Review
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
Metabolic syndrome (MetS) is a cluster of conditions that increases the risk of cardiovascular disease and type 2 diabetes and has been linked to accelerate cellular aging. MetS participants exhibited shorter telomeres and disrupted telomerase activity, suggesting increased biological aging. Lifestyle interventions, particularly high-intensity interval training (HIIT) and mindfulness practices, were associated with telomere elongation and improved telomerase activity, whereas pharmacological approaches showed inconsistent results. Thus, we show the protective role of lifestyle modification, large-scale randomized controlled trials across diverse populations are needed to validate long-term benefits on cellular aging and disease outcomes.
Keywords
Metabolic syndrome, telomere length, telomerase activity, cellular aging, oxidative stress, biomarkers
Citation
Dash et al. Bioinformation 21(9): 3047-3050 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
