Observational cohort study on physical activity patterns and coronary artery calcification among middle-aged adults

Title	Observational cohort study on physical activity patterns and coronary artery calcification among middle-aged adults
Authors	Baishali Biswajit Chatterjee¹, Iqraa Jalil² & S. Yogesh³*
Affiliation	¹Department of Acute Medical Unit (AMU), Royal Victoria Hospital Belfast, Belfast, United Kingdom; ²Department of Stroke Unit, Northern Ireland Medical and Dental Training Agency (NIMDTA), Northern Ireland; ³Department of Internal Medicine, Institute of Internal Medicine, Madras Medical college and Rajiv Gandhi Government General Hospital, MHPE Scholar, Sri Balaji Vidyapeeth University, Pondicherry, India; *Corresponding author
Email	Baishali Biswajit Chatterjee - E-mail: drbaishalichatterjee@gmail.com; Phone: +9107587994569 Iqraa Jalil - E-mail: iqraaj@hotmail.co.uk; Phone: +91 07586599048 S Yogesh - E-mail: yeswhy20@gmail.com; Phone: +91 96001 28033
Article Type	Research Article
Date	Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract	The relationship between physical activity patterns and coronary artery calcification (CAC) among 132 middle-aged adults aged 40–60 years is of interest. Participants were followed over a 2-year period with baseline and follow-up coronary CT scans and activity tracking. Results showed that moderate to high physical activity was significantly associated with lower CAC progression. Sedentary behavior correlated with higher baseline CAC scores and greater progression over time. Thus, we show the importance of sustained physical activity in mitigating early atherosclerotic changes.
Keywords	Physical activity, coronary artery calcification, middle-aged adults, observational cohort, sedentary lifestyle
Citation	Chatterjee et al. Bioinformation 21(9): 3063-3066 (2025)
Edited by	A Prashanth
ISSN	0973-2063
Publisher	Biomedical Informatics
License	This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.