Title

Probiotics and quality of life improvement in cancer therapy

Authors

Himani Muniyal Jheetay¹, Nikhil Menia²,*, Kishore Chandra Thakur³ & Seema Gupta⁴

Affiliation

¹Department of Biochemistry, GEIMS, Dehradun, Uttrakhand, India; ²Department of Pharmacology, AIIMS, Vijaypur, Jammu and Kashmir, India; ³Department of Anatomy, Graphic Era Institute of Medical Sciences, Dehradun, Uttrakhand, India; ⁴Department of Pharmacology GMC Jammu and Kashmir, India; *Corresponding author

Email

Himani Muniyal Jheetay - E-mail: himani580@gmail.com
Nikhil Menia - E-mail: nikhilmenia@gmail.com
Kishore Chandra Thakur - E-mail: kcthakur2601@gmail.com
Seema Gupta - E-mail: vk39se@yahoo.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Gastrointestinal toxicity and mental fatigue are common with cancer therapy by reducing patient quality of life. In this observational study patients taking Lactobacillus probiotic had better role function (6.52 vs 6.20, p=0.016), emotional balance (11.96 vs 11.58, p=0.020) and cognitive clarity (6.42 vs 6.20, p=0.037) after 6 weeks. Diarrhoea severity was lower (0.78 vs 1.26, p<0.001) and fewer needed rescue loperamide (24% vs 44%, p=0.034). Thus, we show probiotics help patients adapt better to treatment stress and protect gut-brain axis during chemotherapy and radiotherapy.

Keywords

Lactobacillus probiotics, cancer therapy, quality of life

Citation

Jheetay et al. Bioinformation 21(9): 3110-3113 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.