Title

Acute kidney injury in chronic liver disease: Causes and prevalence in a cross-sectional study

Authors

Pankaj Kumar Gupta¹, Rahul Soni², Yasha Bandil³, Madhu Saurabh Singh Dhurvey¹* & Sachin Parmar⁴

Affiliation

¹Deprtment of General Medicine, Birsa Munda Government Medical College, Shahdol, Madhya Pradesh, India; ²Department of Pulmonary Medicine, Birsa Munda Government Medical College, Shahdol, Madhya Pradesh, India; 3Department of Ophthalmology, Birsa Munda Government Medical College, Shahdol, Madhya Pradesh, India; ⁴Department of Community Medicine, V.K.S. Government Medical College, Neemuch, Madhya Pradesh, India; *Corresponding author

Email

Pankaj Kumar Gupta - E-mail: dr.pankajgupta89@gmail.com
Rahul Soni - E-mail: Rssonirahul@gmail.com
YashaBandil - E-mail: yashabandil@gmail.com
Madhu Saurabh Singh Dhurvey - E-mail: sdrmadhusaurabh@gmail.com
Sachin Parmar - E-mail: dr.sachinparmar@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Chronic liver disease (CLD) is a prevalent condition with significant systemic complications and acute kidney injury (AKI) is a common and serious complication that worsens prognosis. This prospective observational study, conducted from November 2019 to June 2021 at G.R. Medical College, Gwalior, included 100 CLD patients. The study found that 30% of patients developed AKI, with sepsis as the most common precipitating factor. Severe renal impairment (Stage 3 AKI) was present in 46.6% of AKI cases. Alcohol was the leading etiology of CLD and the timely diagnosis and management of AKI in CLD patients are essential to improving outcomes and reducing mortality.

Keywords

Chronic liver disease, acute kidney injury, hepatic decompensation, sepsis, alcoholic liver disease

Citation

Gupta et al. Bioinformation 21(9): 3118-3122 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.