Title
Urinary nephrin - An emerging novel biomarker in early detection of diabetic nephropathy: A review
Authors
Ramagiri Sateesh & Kurpad Nagaraj Shashidhar*
Affiliation
Department of Biochemistry, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar, Karnataka, India; *Corresponding author
Ramagiri Sateesh - E-mail: rsateeshphdbiochem@gmail.com
Kurpad Nagaraj Shashidhar - E-mail: drshashikn1971@yahoo.co.in
Article Type
Review
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
Diabetic nephropathy is a microvascular complication of uncontrolled diabetes mellitus. Diabetic nephropathy is characterized by persistent albuminuria, hypertension and a progressive decline in the glomerular filtration rate. Early detection of diabetic nephropathy is crucial for the management of complications. Urinary Nephrin is an emerging biomarker that has been implicated in early detection of diabetic nephropathy. Nephrin is a podocyte-specific protein that maintains glomerular filtration barrier integrity. Alterations in Nephrin expression and urinary excretion are signs of renal impairment in diabetic nephropathy. Therefore, it is of interest to establish a biological reference interval and standardize the assay method. Hence, an update on this emerging biomarker is relevant.
Keywords
Diabetes mellitus, diabetic nephropathy, urinary nephrin and biomarker
Citation
Sateesh & Shashidhar, Bioinformation 21(9): 3123-3129 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
