Title

Antibacterial efficacy and compressive strength of modified glass ionomer cements

Authors

Kalyana Ponangi¹*, Satish Venkata Sarvepalli², Anil Kumar Venkeshwarlu James³, Sandeep Pasumarthy⁴, Srisha Neshangi¹ & Sruthi Katamneni⁵

Affiliation

¹Noble Community Clinics, Wautoma, Wisconsin, USA; ²Department of Conservative Dentistry, Navodaya Dental College, Karnataka, India; ³Jefferson Dental and Orthodontics, San Antonio, Texas, USA; ⁴Affordable Dentures and Implants, Danville, Virginia, USA; ⁵Prosmiles Dental, Plano, Texas, USA; *Corresponding author

Email

Kalyana Ponangi - E-mail: Kalyan.ponangi@gmail.com
Satish Venkata Sarvepalli - E-mail: drsatishdent@gmail.com
Anil Kumar Venkeshwarlu James - E-mail: Vj.anilkumar.mds@gmail.com
Sandeep Pasumarthy - E-mail: Sandeep.pasumarthy@gmail.com
Srisha Neshangi - E-mail: srineshangi@gmail.com
Sruthi Katamneni - E-mail: Katamneni.sruthi27@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Incorporation of antibacterial agents into restorative materials often compromises the physical properties of glass ionomer cement (GIC). Therefore, it is of interest to evaluate the antibacterial efficacy and compressive strength of FUJI IX GIC modified with 2% chlorhexidine, 1% cetrimide, 2.5% triclosan, or 1.5% antibiotics (metronidazole, minocycline and ciprofloxacin), added to the powder at a powder-liquid ratio of 3.6/1. Compressive strength was assessed using 50 cylindrical specimens (4 mm diameter, 6 mm height, 10 per group) tested on a Universal Testing Machine, while antibacterial efficacy was evaluated via agar diffusion on 50 disc-shaped specimens (10 mm diameter, 2 mm thickness, 10 per group) measuring inhibition zones on BHI agar. Statistical analysis involved ANOVA followed by Dunnett's t-test, with p < 0.05 considered significant; all modified GICs exhibited antibacterial activity but showed significantly reduced compressive strength compared to the control. The antibiotic-modified GIC demonstrated superior antibacterial efficacy and compressive strength among the experimental groups, though the control group had the highest overall compressive strength.

Keywords

Glass ionomer cement; antibacterial efficacy; compressive strength

Citation

Ponangi et al. Bioinformation 21(9): 3135-3139 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.