Title
Retrospective evaluation of correlation of ABO blood groups among patients with head and neck cancer
Authors
Santoshkumar Kotnoor1,*, Shweta Hegde2, Shubhra Raghav3, Abida Khatun2, Paridhi Sharma2, Shobhit K Saxena4, Miral Mehta5 & Jugajyoti Pathi6
Affiliation
1Department of Oral Pathology and Microbiology, HKE’s Society S Nigligappa Dental College and Research, Kalaburagi, Karnataka, India; 2Department of Oral Medicine and Radiology, Triveni Institute of Dental Science Hospital and Research Centre, Bilaspur, Chhattisgarh, India; 3Department of Public Health Dentistry, Kothiwal Dental College & Research Centre, Moradabad, Uttar Pradesh, India; 4Department of Orthodontics and Dentofacial Orthopaedics, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat-384315, India; 5Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; 6Department of Oral & Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University. Bhubaneswar, Odisha, India; *Corresponding author
Santoshkumar Kotnoor - E-mail: santoshvevaan@gmail.com
Shweta Hegde - E-mail: drshwetashetty@gmail.com
Shubhra Raghav - E-mail: shubhra.raghav@gmail.com
Abida Khatun - E-mail: abidakhatun99@gmail.com
Paridhi Sharma - E-mail: drparidhis@gmail.com
Shobhit K Saxena - E-mail: shobhit.fds@spu.ac.in
Miral Mehta - E-mail: miral9829@gmail.com
Jugajyoti Pathi - E-mail: jpathi@kims.ac.in
Article Type
Research Article
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
Head and neck cancer (HNC) is a multifactorial disease influenced by genetic and environmental factors. This retrospective case-control study examined the relationship between ABO blood groups and the risk of HNC in 542 patients and 1084 controls. Blood group A was significantly associated with increased HNC risk (OR = 1.42, p = 0.004), particularly for oral cavity cancers, while blood group O showed a borderline protective effect. No significant associations were noted for blood groups B or AB. Thus, we show ABO blood group may play a role in HNC susceptibility.
Keywords
Head and neck cancer, ABO blood group, oral cavity cancer, genetic susceptibility, risk factors.
Citation
Kotnoor et al. Bioinformation 21(9): 3181-3185 (2025)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
