Title
Analytical cohort study on intraoperative hypotension as a risk factor for postoperative acute kidney injury
Authors
Vishal Mruthyunjaya Kalmani1, Dhyaneshwar Ra2,*, Yeruva Bheemeswara Reddy3 & Poornima Venkatraman4
Affiliation
1Department of Surgery, Barking Havering and Redbridge University Hospitals NHS Trust, Essex, United Kingdom; 2Department of Emergency of General Surgery, Government Stanley Medical College Chennai, Tamil Nadu, India; 3Department of Surgery, Santhiram Medical College, Andhra Pradesh, India; 4Department of Surgery, Davao Medical School Foundation, Philippines; *Corresponding author
Vishal Mruthyunjaya Kalmani - E-mail: vishal.kalmani@nhs.net; Phone:
+447405881521
Dhyaneshwar Ra - E-mail: radhyaneshwar@gmail.com; Phone: +91
7010378943
Poornima Venkatraman - E-mail: poornimavenkatraman96@gmail.com;
Phone: +91 9652696432
Yeruva Bheemeswara Reddy - E-mail: Bheemesh.yeruva@gmail.com; Phone:
+91 7095918515
Article Type
Research Article
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
Acute kidney injury (AKI) is a serious complication that happens after surgery and intraoperative hypotension (IOH) is a modifiable risk factor. We did a cohort analytical study consisting of 145 adult patients who were undergoing major non-cardiac surgery under general anesthesia. Patients who were diagnosed with IOH (defined as mean arterial pressure <65 mmHg for ≥15 minutes), had significantly higher rates of postoperative AKI. Multivariate analysis confirmed independent predictors of AKI including IOH, chronic kidney disease, and prolonged operative time. Overall, this study highlights the importance of hemodynamic monitoring and the continuing maintenance of MAP ≥65 mmHg as a potential way to reduce renal complications.
Keywords
Mean arterial pressure, acute renal damage, perioperative risk, analytical cohort studies, intraoperative hypotension
Citation
Kalmani et al. Bioinformation 21(9): 3223-3226 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
