Title
Comparison of salivary carcino embryonic antigen among tobacco users without lesions, oral potentially malignant disorders and oral squamous cell carcinoma
Authors
Padmanathan Renganathan*, B. G Harsha Vardhan, Srividhya Srinivasan & K Saraswathi Gopal
Affiliation
Department of Oral Medicine and Radiology, Meenakshi Ammal Dental College, Maher University, Chennai, India; *Corresponding author
Padmanathan Renganathan - E-mail: padmanathanr05@gmail.com; Phone:
+91 7305988086
B. G Harsha Vardhan - E-mail: bgharshavardhan@yahoo.com
Srividhya Srinivasan - E-mail: drsrividhya.omrd@madch.edu.in
K Saraswathi Gopal - E-mail: dr.saraswathik@gmail.com
Article Type
Research Article
Date
Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025
Abstract
Oral cancer, mainly oral squamous cell carcinoma (OSCC), is a common head and neck malignancy affecting multiple oral sites. This study compared salivary carcinoembryonic antigen (CEA) levels among tobacco users without lesions, patients with oral potentially malignant disorders (OPMDs), and OSCC patients. Thirty subjects were divided into three groups of ten, and unstimulated saliva samples were collected and analyzed using a Can Ag Diagnostics ELISA kit. Data analysis was performed using SPSS v26, with means compared by one-way ANOVA and t-tests. Results showed CEA levels were highest in OSCC, followed by OPMDs and tobacco users, suggesting its role as a non-invasive biomarker for early malignant transformation.
Keywords
Carcino embroyogenic antigen, oral cancer, oral potentially malignant disorder
Citation
Renganathan et al. Bioinformation 21(9): 3239-3241 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
