Title

Role of osteoporosis and diabetes on facial and long bone fracture healing under various loading conditions

Authors

Pradeep V Pattar^1,*, P Veeranan Yadav², Neha Jain³, Ishaan Saha⁴, Aaquib Nazir⁵, Preeti Dhir⁶, Miral Mehta⁷ & Jugajyoti Pathi⁸

Affiliation

¹Department of Oral and Maxillofacial Surgery & Implantology, The Oxford dental College, Bengaluru, India; ²Department of Orthopaedics, Government Royapettah Hospital, Chennai, Tamil Nadu, India; ³Department of Oral and Maxillofacial Surgery, People's Dental Academy, Bhopal, Madhya Pradesh, India; ⁴Department of Dental Surgery, Sri Ramachandra Dental College & Hospital, SRIHER, Porur, Chennai, Tamil Nadu, India; ⁵Department of Dentistry, SNM District Hospital, Leh, UT Ladakh, India; ⁶Department of Oral Medicine and Radiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India; ⁷Department of Pediatric and Preventive Dentistry, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; ⁸Department of Oral & Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India; *Corresponding Author

Email

Pradeep V Pattar- E-mail: drpattarpradeep@gmail.com

P VeerananYadav- E-mail: drveeru74@yahoo.co.in

Neha Jain- E-mail: nehamds26@yahoo.in

Ishaan Saha- E-mail: drishaansaha23@gmail.com

Aaquib Nazir- E-mail: dr.aaquib.nazir@gmail.com

Preeti Dhir- E-mail: drpreetikumra@yahoo.in 

Miral Mehta- E-mail: miral9829@gmail.com

Jugajyoti Pathi- E-mail: jpathi@kims.ac.in

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The independent and combined effects of osteoporosis and diabetes on mandibular and tibial fracture healing under varied mechanical loading in a rat model (n=120) is of interest. Osteoporosis and diabetes each impaired healing, with comorbid rats showing the most severe reductions in BMD (Bone Mineral Density) and biomechanical strength. Cyclic loading worsened outcomes in diabetic rats, while reduced loading benefited osteoporotic fractures. Disarranged angiogenesis and collagen organization in comorbid groups is confirmed histologically. Thus, we show the need to customize various procedures in patients with systemic comorbidities.

Keywords

Fracture healing, osteoporosis, diabetes mellitus, mechanical loading, bone regeneration.

Citation

Pattar et al. Bioinformation 21(9): 3305-3308 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.