Title

Patterns of oral squamous cell carcinoma among smokeless tobacco users: A clinical study

Authors

Damarasingu Rajesh¹*, Meghana Voddiraju², Anil Managutti², Venkat Hemant Akurati³, Jagadish Prasad Rajguru⁴, Ancy Kuriakose⁵, Heena Dixit⁶ & Rahul Tiwari¹

Affiliation

¹Department of Oral and Maxillofacial Surgery, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India; ²Department of General Medicine, Government Medical College, Nizamabad, Telangana, India; ³General Dentistry, University of Louisville, School of Dentistry, Louisville, Kentucky, USA; ⁴Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India; ⁵Department of oral medicine and radiology, St. Gregorios dental college, Kothamangalam, Chelad, Kerala, India; ⁶Department of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India; *Corresponding author

Email

Damarasingu Rajesh - E-mail: rajeshoralsurgeon@gmail.com
Meghana Voddiraju - E-mail: meghana.voddirajurao@gmail.com
Anil Managutti - E-mail: dranilman12@gmail.com
Venkat Hemant Akurati - E-mail: hemantakurati94@gmail.com
Jagadish Prasad Rajguru - E-mail: drgurumdsop@gmail.com
Ancy Kuriakose - E-mail: ancyk336@gmail.com
Heena Dixit - E-mail: drheenatiwari@gmail.com
Rahul Tiwari - E-mail: drrahulvctiwari@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

Subsite distribution, mandibular invasion patterns, nodal involvement and survival outcomes in oral squamous cell carcinoma (OSCC) patients with a history of smokeless tobacco (SLT) use is of interest. Gingivobuccal complex (GBC) subsites were predominant, with frequent mandibular marrow involvement. Two- and five-year overall survival rates approximated 95% and 79%, respectively. Thus, data shows the clinical behavior of SLT-associated OSCC and underscore the importance of targeted imaging and early detection.

Keywords

Oral squamous cell carcinoma, smokeless tobacco, gingivobuccal complex, mandibular neoplasms, survival analysis

Citation

Rajesh et al. Bioinformation 21(9): 3314-3316 (2025)

Edited by

Akshaya Ojha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.