Title

Cross-sectional analysis of gut microbiome diversity with progression of Alzheimer's disease

Authors

Prashant Sundeep Gupta¹, Vedanth Mayakrishna Padmakumar² & Omar Imtiaz Usmani³,*

Affiliation

¹Department of Medicine, Surat Municipal Institute of Medical Education and Research, Smimer, Gujarat, India; ²Department of Casualty, Casualty Medical Officer, Kerala, India; ³Department of General Medicine, Era's Lucknow Medical college Lucknow, Uttar Pradesh, India; *Corresponding author

Email

Prashant Sundeep Gupta - E-mail: prashant2072@gmail.com
Vedanth Mayakrishna Padmakumar - E-mail: vedanth1993@gmail.com
Omar Imtiaz Usmani - E-mail: omarusmani2001@gmail.com

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The relationship between gut microbiome diversity and stages of Alzheimer's disease (AD) progression is of interest. Hence, a total of 124 participants, including cognitively normal controls and patients with mild, moderate, and severe AD, were assessed for microbiome composition using 16S rRNA sequencing. Results revealed significantly reduced microbial diversity and altered bacterial profiles, notably lower levels of Bifidobacterium and Faecalibacterium and increased Proteobacteria, in advanced AD stages. Correlations were observed between cognitive declines and reduced alpha diversity. Thus, we show gut dysbiosis may play a contributory role in Alzheimer’s pathology.

Keywords

Gut microbiome, Alzheimer's disease, cognitive decline, dysbiosis, 16S rRNA sequencing

Citation

Gupta et al. Bioinformation 21(9): 3329-3332 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.