Title

Prospective cohort study on the relationship between long-term air pollution exposure and risk of myocardial infarction

Authors

Rahil Abdusamad Nainam Valappil¹, Anjaly Mecheril Chandran², Shameela Farha³*, Sachin Puthusseriyil Shaji⁴, Yash Sharan⁵, Yashita Dharni⁶ & Smarin Shaji⁷

Affiliation

¹Department of Critical Care, Iqraa International Hospital, Calicut, Kerala, India; ²Department of Gastro Medicine, Malankara Orthodox Syrian Church Medical Mission Hospital, Kolenchery, Kerala, India; ³Department of Emergency Medicine, Calicut Hospital & Nursing home, Calicut, Kerala, India; ⁴Department of Emergency Medicine, General Hospital, Muvattupuzha, Kerala, India; ⁵Department of Anesthesia and Critical Care, Lok Nayak Hospital, New Delhi, India; ⁶Department of General Medicine, Adesh Institute of Medical Sciences and Research (AIMSR), Bathinda, Punjab, India; ⁷Department of Traditional Medicine, University of Traditional Medicine, Yerevan, Armenia; *Corresponding author

Email

Rahil Abdusamad Nainam Valappil - E-mail: rahilnv007@gmail.com; Phone: +91 9747651918
Anjaly Mecheril Chandran - E-mail: anjaly.mc@gmail.com; Phone: +91 9074087434
Shameela Farha - E-mail: shameelafarha@gmail.com; Phone: +91 9482456434
Sachin Puthusseriyil Shaji - E-mail: sachinshaji95027@gmail.com; Phone: +91 6362377728
Yash Sharan - E-mail: yashsharan98@gmail.com; Phone: +91 9431426439
Yashita Dharni - E-mail: yashitauk997@gmail.com; Phone: +91 9815849308
Smarin Shaji - E-mail: 1611smarinshaji2000@gmail.com; Phone: +91 8281981491

Article Type

Research Article

Date

Received September 1, 2025; Revised September 30, 2025; Accepted September 30, 2025, Published September 30, 2025

Abstract

The relationship between long-term air pollution exposure and risk of myocardial infarction is of interest. Hence, this five-year prospective cohort study examined 132 adults between the ages of 40 and 65 to determine whether long-term exposure to air pollutants (PM2.5, NO₂, and SO₂) was associated with an increased risk of myocardial infarction (MI). Participants who lived in metropolitan regions with high pollution levels had a noticeably higher incidence of MI than those who lived in locations with low exposure levels. According to adjusted risk models, PM2.5 is the most reliable independent predictor of MI incidence. High-exposure individuals also showed significantly higher levels of biomarkers of systemic inflammation. In order to reduce cardiovascular risks, the results highlight the necessity of strict air quality restrictions.

Keywords

Air pollution, myocardial infarction, cardiovascular risk, PM2.5, and prospective cohort studies

Citation

Valappil et al. Bioinformation 21(9): 3413-3416 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.