Title

Evaluation of salivary lactate dehydrogenase level among tobacco users - A hospital based study

Authors

Anvita Sinha¹, Nitesh Kumar Sharma¹, Sudhanshu Saxena^1,*, Anushree Prasad², Sonia Tiwari³, Amit Raj⁴, Sayantan Bhattacharya⁵, Medha Krishnan¹ & Amarta Lakra¹

Affiliation

¹Department of Dentistry, M.G.M. Medical College and Hospital, Jamshedpur, Jharkhand, India; ²Department of Conservative Dentistry and Endodontics, Awadh Dental College & Hospital, Jamshedpur, Jharkhand, India; ³Department of Pediatric and Preventive Dentistry, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, India; ⁴Private Practitioner, Dant Aarogya Hospital, Biharsharif (Nalanda), Bihar, India; ⁵Medical TCIL, Tata Steel Ltd, Jamshedpur, Jharkhand, India; *Corresponding author

Email

Anvita Sinha - E-mail: dranvitasinha11@gmail.com
Nitesh Kumar Sharma - E-mail: drniteshsharma@yahoo.com
Sudhanshu Saxena - E-mail: dr.sudhanshusaxena@gmail.com
Anushree Prasad - E-mail: anushreeprasad25@gmail.com
Sonia Tiwari - E-mail: soniatiwari2006@gmail.com
Amit Raj - E-mail: amithcdsh@gmail.com
Sayantan Bhattacharya - E-mail: sayantan.jam@gmail.com
Medha Krishnan - E-mail: medha.krishnan99@gmail.com
Amarta Lakra - E-mail: lakraamarta@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

Salivary lactate dehydrogenase (LDH) holds promise as a screening tool for early oral mucosal changes, including precancers and cancers, often linked to tobacco use. This study evaluated salivary LDH levels across 135 patients from the dental outpatient department at M. G. M. Medical College and Hospital, Jamshedpur, Jharkhand, India. Participants were categorized into three groups (n=45 each): non-tobacco users (controls), tobacco users without oral lesions and tobacco users with oral lesions. Unstimulated saliva samples were collected, centrifuged and analyzed for LDH levels. Results revealed significantly highest salivary LDH levels in tobacco users with lesions, followed by tobacco users without lesions and then the control group. These findings suggest that salivary LDH could be a valuable biomarker for detecting pathological changes in the oral mucosa of tobacco users.

Keywords

Biomarker, oral precancers, oral cancer, salivary lactate dehydrogenase, tobacco

Citation

Sinha et al. Bioinformation 21(10): 3442-3446 (2025)

Edited by

Akshaya Ojha

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.