Title

Analytical cohort study on cognitive reserve as a predictor of post-stroke dementia severity

Authors

Shreya Krishna¹, Subash Kumar², L. Elakkiya³, Shanmukha Koppolu⁴, Shabrin Abdul Rasheed⁵, Vijaya Madhuri Devi Kunche^6,* & Ayush Bhardwaj⁷

Affiliation

¹Department of Medicine, Nottingham University Hospitals NHS Foundation Trust, Nottinghamshire, United Kingdom; ²General Practitioner, General Medicine, Madras Medical College, Chennai, India; ³Department of General Medicine, Madras Medical College, Chennai, India; ⁴Department of Trauma and Orthopaedics, Barts NHS Trust, London, England, United Kingdom; ⁵Department of Emergency Medicine, Basildon University Hospital, Nethermayne, Basildon, Essex, SS16 5NL, United Kingdom; ⁶Department of Critical Care Medicine, Dr. NTR University of Health Sciences, Vijayawada, Andhra Pradesh; ⁷Internal Medicine, Manipal Academy of Higher Education (MAHE), Karnataka, India; *Corresponding author

Email

Shreya Krishna - E-mail: shre1496@gmail.com; Phone: +91 7949528996
Subash Kumar - E-mail: nksubashmass@gmail.com; Phone: +91 8939534193
L. Elakkiya - E-mail: elakkiya0909@gmail.com; Phone: +91 9994993801
Shanmukha Koppolu - E-mail: kshanmukha3@gmail.com; Phone: +447448304208
Shabrin Abdul Rasheed - E-mail: shabrin.rasheed@nhs.net; Phone: +91 9961913539
Vijaya Madhuri Devi Kunche - E-mail: srimadhuri1717@gmail.com; Phone: +91 9494145588
Ayush Bhardwaj - E-mail: dr.bhardwaj.ayush@gmail.com; Phone: +91 9521870063

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

The role of cognitive reserve in determining the severity of dementia following a stroke in individuals aged 55 and above is of interest. Hence, a total of 128 stroke survivors were followed for 12 months post-event, with cognitive reserve quantified using education level, occupational attainment and engagement in cognitive activities. Higher cognitive reserve scores were associated with milder post-stroke dementia outcomes and better functional independence. Thus, we show that cognitive reserve is a significant protective factor against severe cognitive decline after stroke.

Keywords

Cognitive reserve, post-stroke dementia, stroke survivors, dementia severity, neuroprotection, cognitive aging, education, occupational complexity, longitudinal analysis, neuroplasticity

Citation

Krishna et al. Bioinformation 21(10): 3480-3483 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.