Title

Sleep deprivation as a risk factor for cognitive decline among middle-aged adults

Authors

Debadrit Biswas¹, Pooja Saithya Pillarisetti², Achyuth Prasad Jakka³ & Subash Kumar^4,*

Affiliation

¹Department of Neurology, Ruby General Hospital, West Bengal, India; ²Department of General Medicine, A.C.S.R Government Medical College Nellore, Andhra Pradesh, India; ³General Medicine, Government Medical College, Anantapuramu, Andhra Pradesh, India; ⁴Department of General Medicine, Madras Medical College, Chennai, India; *Corresponding author

Email

Debadrit Biswas - E-mail: biswasdebadrit@gmail.com; Phone: +91 9830796861/8240976382
Pooja Saithya Pillarisetti - E-mail: pillarisettipoojasaithya@gmail.com; Phone: +17343856478
Achyuth Prasad Jakka - E-mail: achuthachuth2@gmail.com; Phone: +91 8465870029
Subash Kumar - E-mail: nksubashmass@gmail.com; Phone: +91 8939534193

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

The impact of chronic sleep deprivation on cognitive decline among 140 middle-aged adults aged 40–60 years over a 3-year period is of interest. Participants were assessed using standardized cognitive batteries and sleep tracking devices. Data revealed that individuals sleeping less than 6 hours per night had significantly greater declines in memory, executive function and attention. These associations remained significant after adjusting for confounders such as age, sex and comorbidities. Chronic insufficient sleep appears to be an independent predictor of accelerated cognitive decline.

Keywords

Sleep deprivation, cognitive decline, prospective study, middle-aged adults, memory impairment

Citation

Biswas et al. Bioinformation 21(10): 3484-3487 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.