Title
Comparative study on salivary IL- 8 and LDH among tobacco users without lesions, leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma
Authors
Srinivasan Venkatesh*, K. Saraswathi Gopal & Nandhini Ganesan
Affiliation
Department of Oral medicine and Radiology, Meenakshi Ammal Dental College and Hospital, MAHER University, Chennai, India; *Corresponding author
Srinivasan Venkatesh - E-mail: srinivenkey4@gmail.com, Phone: +91
9790745873
K Saraswathi Gopal - E-mail: dr.saraswathik@gmail.com
Nandhini Ganesan - E-mail: drnandhini.omrd@madch.edu.in
Article Type
Research Article
Date
Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025
Abstract
Oral and oropharyngeal malignancies, OSCC accounts for 95% of cases. Diagnosis and prognosis of OSCC relies upon the tumour staging, an important predictor of survival. Therefore, it is of interest to evaluate the changes in the salivary levels of IL-8 and LDH among Tobacco users without lesions, Individuals with Leukoplakia, Oral submucous fibrosis and OSCC. 40 cases were analysed in this study. We show that salivary IL8 and LDH which can serve as one reliable biomarker in early detection of OSCC and a prognostic indicator for OPMDs.
Keywords
Interleukin-8, Lactate dehydrogenase (LDH), oral squamous cell carcinoma, saliva, ELISA
Citation
Venkatesh et al. Bioinformation 21(10): 3542-3545 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
