Title
Enamel remineralizing potential of three different agents - A qualitative and quantitative analysis
Authors
Bhavana Badaka, Vijetha Badami*, Juveria Masreen, V. Yoshna Sree, G. Sanjana Reddy & J. Tarun Teja
Affiliation
Department of Conservative Dentistry and Endodontics, MNR Dental College and Hospital, Sangareddy, Telanagana, India; *Corresponding author
Bhavana Badaka - E-mail: dr.bhavana.badaka@gmail.com
Vijetha Badami - E-mail: vijetha.mds@gmail.com
Juveria Masreen - E-mail: drjuveriamasreen@gmail.com
V. Yoshna Sree - E-mail: yoshnasree17@gmail.com
G. Sanjana Reddy - E-mail: g.sanjanareddy17@gmail.com
J. Tarun Teja - E-mail: tharun24300@gmail.com
Article Type
Research Article
Date
Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025
Abstract
Dental enamel is susceptible to acid-induced demineralization and while fluoride treatments are effective, they have limitations such as superficial remineralization and risk of fluorosis. This in vitro study examined the remineralization potential of calcium phosphate (CaP) nanoparticles, bioactive glass (BAG) nanoparticles and nano-hydroxyapatite (nHAp) on artificially demineralized human enamel. Energy-dispersive X-ray spectroscopy and Vickers microhardness were used to assess the 60 premolars after they were prepared, separated into four groups (control, CaP, nHAp and BAG), demineralized and treated daily for seven days. All nanoparticle groups showed significant remineralization versus control, with nHAp achieving the highest hardness and Ca/P ratio, followed by BAG and CaP. Thus, we show nHAp as the most effective non-invasive remineralizing agent for early carious lesions.
Keywords
Dental caries, enamel remineralization, Artificial saliva, nanoparticles, energy dispersive X‑ray, vickers hardness number
Citation
Badaka et al. Bioinformation 21(10): 3587-3591 (2025)
Edited by
Akshaya Ojha
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
