Title

Longitudinal study evaluating the role of physical activity in modifying Parkinson's disease progression

Authors

Deepak C Rathod¹, Samidha Utkarsh Kurdikar², Mounica Ratnala^3,*, Rajput Nixitsinh Arvindsinh⁴ & Priya Goyal⁵

Affiliation

¹Department of Clinical Haematology, University Hospital of Wales, Cardiff, United Kingdom; ²Department of General Medicine, Healthway Hospital, Goa, India; ³Department of Medicine, A.C.S.R Government Medical College, Nellore andhra Pradesh, India; ⁴Department of Medicine, ITM hospital, Gwalior, Madhya Pradesh, India; ⁵Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India; *Corresponding author

Email

Deepak C Rathod - E-mail: drathod77@gmail.com; Phone: +447538521034
Samidha Utkarsh Kurdikar - E-mail: drsamidhanaik@gmail.com; Phone: +91 9511671976
Mounica Ratnala - E-mail: mouniratnala@gmail.com; Phone: +91 9014247437
Rajput Nixitsinh Arvindsinh - E-mail: nixit22999@gmail.com; Phone: +91 8469166796
Priya Goyal - E-mail: priyagoyal1123@yahoo.com

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

The role of physical activity in modifying Parkinson's disease progression is of interest. This longitudinal study followed 118 patients with idiopathic Parkinson's disease over 24 months to evaluate the impact of physical activity on disease progression. Participants were grouped based on physical activity levels sedentary, moderately active and highly active using standardized activity questionnaires. Disease severity was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr staging. Patients with higher physical activity levels showed slower motor and functional decline compared to sedentary individuals. Thus, we show that regular physical activity may positively influence the trajectory of Parkinson's disease.

Keywords

Parkinson's disease, physical activity, disease progression, motor symptoms, UPDRS

Citation

Rathod et al. Bioinformation 21(10): 3612-3616 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.