Title
Longitudinal study of chronic stress effects on epilepsy prevalence
Authors
Gervais Singh Samra1,*, Saika Nazir2, Shanmukha Koppolu3 & Melanie Mary Francis4
Affiliation
1Department of Gastroenterology, Royal Wolverhampton NHS Trust, Wolverhampton, County of West Midlands, England, United Kingdom; 2Department of Clinical Attache (psychiatry), Psychiatry Consultant at GMC, Srinagar, Jammu and Kashmir, India; 3Department of Trauma and Orthopaedics, Barts NHS Trust, London, England/ UK; 4Department of Psychiatry, Alphonsa Hospital, Pullorampara, Calicut, Kerala, India; *Corresponding author
Gervais Singh Samra - E-mail: gervaissamra3@gmail.com; Phone: +44
7587751409
Saika Nazir - E-mail: Khansasha1493@gmail.com; Phone: +91 7889490499
Shanmukha Koppolu - E-mail: kshanmukha3@gmail.com; Phone:
+447448304208
Melanie Mary Francis - E-mail: francismelanie707@gmail.com; Phone:
+91 9847901917
Article Type
Research Article
Date
Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025
Abstract
The relationship between chronic stress exposure and epilepsy prevalence in adults over a 3-year follow-up period is of interest. Hence, a cohort of 145 stress-exposed individuals and matched controls were assessed using validated stress scales and neurological evaluations. Chronic stress was found to significantly increase the risk of new-onset epilepsy, particularly in those with comorbid anxiety and sleep disorders. Neuroinflammatory and neuroendocrine mechanisms are suggested as mediators. Thus, we show the need for early stress intervention in epilepsy prevention.
Keywords
Chronic stress, epilepsy, neuroinflammation, longitudinal cohort, seizure threshold, HPA axis, allostatic load, sleeps disturbance, mental health and neurologic risk factors
Citation
Samra et al. Bioinformation 21(10): 3617-3620 (2025)
Edited by
A Prashanth
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
