Title

Assessing anti-plaque efficiency of a herbal dentifrice

Authors

Debadrita Ghosh^1,*, Vishal Yadav², Sonia Sharma³, A Nagaraja⁴, Nandini Komaravelli⁵ & Shalini Singh⁶

Affiliation

¹Department of Pediatric & Preventive Dentistry, Consultant Pedodontist, Kolkata, West Bengal, India; ²Department of Dentistry, Government Medical College, Bundi, Rajasthan, India; ³Department of Dentistry, Maharaja Agrasen Medical College, Agroha, Haryana, India; ⁴Department of Oral & Maxillofacial Pathology, Seema Dental College & Hospital, Rishikesh, Uttarakhand, India; ⁵Department of Periodontology and Implantology, SVS Institute of Dental Sciences, Mahbubnagar, Telangana, India; ⁶Department of Pedodontics & Preventive Dentistry, Safdarjung Hospital, New Delhi, India; *Corresponding author

Email

Debadrita Ghosh - E-mail: debadrita.ghosh12@gmail.com
Vishal Yadav - E-mail: drvishalsinghyadav916@gmail.com
Sonia Sharma - E-mail: mamcashutosh@gmail.com
A Nagaraja - E-mail: nagsdoc@gmail.com
Nandini Komaravelli - E-mail: nandinikomaravelli94@gmail.com
Shalini Singh - E-mail: drshalini.singh826@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

Dental plaque is a key factor in gingivitis and periodontitis, requiring effective control measures. This randomized, double-blind clinical trial compared an herbal dentifrice (neem, clove, tea tree oil), a conventional fluoride dentifrice, and a placebo in 90 participants with mild gingivitis. Plaque Index (PI) and Gingival Index (GI) were recorded at baseline, 2 weeks, and 4 weeks. At 4 weeks, the herbal dentifrice showed the greatest reductions in PI (60.7%) and GI (55.7%) compared to fluoride (48.6%, 41.8%) and placebo (21.4%, 13.2%), with significant intergroup differences (p < 0.001). The herbal dentifrice demonstrated superior anti-plaque and anti-gingivitis efficacy, supporting its role as a natural oral hygiene alternative.

Keywords

Herbal dentifrice, dental plaque, gingivitis, clinical trial, oral hygiene, Azadirachta indica, Syzygium aromaticum, Melaleuca alternifolia

Citation

Ghosh et al. Bioinformation 21(10): 3828-3831 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.