Title

Assessing healing of periapical pathologies by platelet-rich fibrin: A clinical study

Authors

Deepak Sharma¹, Preeti Bhadouria², Pinky Chaurasia³, Surbhi Patel⁴, Devanshi Vaghela⁵ & Hemal Patel⁶

Affiliation

¹Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth (Deemed to be) University Dental College and Hospital, Navi Mumbai, India; ²Department of Oral Medicine & Radiology, Maharana Pratap college of Dentistry & Reasearch Centre, Gwalior, Madhya Pradesh, India; ³Department of Pedodontic and Preventive Dentistry, Triveni Institute of Dental Science and Research Center, Bodri, Bilaspur, Chhattishgarh, India; ⁴Consultant Endodontist, Ahmedabad, Gujarat, India; ⁵Department of Oral & Maxillofacial Surgery, Karnavati School of Dentistry, Karnavati University, Gandhinagar, Gujarat, India; ⁶Department of Public Health Dentistry, Faculty of Dental Science, Dharmsinh Desai University, Nadiad – 387003, Gujarat, India; *Corresponding author

Email

Deepak Sharma - E-mail: deepakdent@gmail.com
Preeti Bhadouria - E-mail: drpreetibhadouria@gmail.com
Pinky Chaurasia - E-mail: dr.chaurasia.pinky@gmail.com
Surbhi Patel - E-mail: surbhipatel.well01@gmail.com
Devanshi Vaghela - E-mail: devanshivaghela8@gmail.com
Hemal Patel - E-mail: phemal87@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised October 31, 2025; Accepted October 31, 2025, Published October 31, 2025

Abstract

One of the ongoing clinical challenges in endodontic microsurgery is the regeneration of massive periapical lesions. Hence, a Forty patients participated in this randomized controlled clinical experiment to see how well platelet-rich fibrin (PRF) worked as a scaffold for regeneration in comparison to the body's inherent ability to mend blood clots. The decrease in lesion volume, pain ratings, and the repair of soft tissues were evaluated at 6 and 12 months by CBCT. PRF demonstrated a much higher rate of bone regeneration (85.2% vs. 64.8%, p < 0.001) and reduced levels of post-operative discomfort on days 1 and 3. Thus, we show that PRF is an inexpensive and easy way to improve the predictability of recovery after periapical surgery.

Keywords

Platelet-rich fibrin, periapical lesion, endodontic microsurgery, bone regeneration, guided tissue regeneration.

Citation

Sharma et al. Bioinformation 21(10): 3912-3916 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.