Title

Pharmacogenomics of surgical stress response in elective abdominal surgeries

Authors

Tirth Hareshkumar Vyas¹, Mahi Jayeshbhai Khiloshiya², Nisha Jayantilal Parmar³, Shreya Girishbhai Kaneria⁴ & Megha Bhaumik Patel^5,*

Affiliation

¹Department of Medicine, B.J. Medical College, Ahmedabad, Gujarat, India; ²Department of Casualty, GMERS Medical College and Civil Hospital, Junagadh, Gujarat, India; ³Department of Pathology, Dr. N.D. Desai Faculty of Medical Science and Research, Dharmsinh Desai University, Nadiad, Gujarat, India; ⁴Department of Medicine, GMERS Medical College and Civil Hospital, Junagadh, Gujarat, India; ⁵Department of Public Health, Long Island University, USA; *Corresponding author

Email

Tirth Hareshkumar Vyas - E-mail: vyastirth.h@gmail.com
Mahi Jayeshbhai Khiloshiya - E-mail: maahi26.v@gmail.com
Nisha Jayantilal Parmar - E-mail: nisha.parmar1188@gmail.com
Shreya Girishbhai Kaneria - E-mail: shreyagk29@gmail.com
Megha Bhaumik Patel - E-mail: mishticare4@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

The variability in surgical stress response among patients undergoing elective abdominal surgeries remains inadequately understood, particularly in relation to genetic polymorphisms influencing drug metabolism and pain modulation. Hence, this study explored the association between key pharmacogenetic variants (CYP2D6, CYP3A4, OPRM1, COMT) and biomarkers of surgical stress response. A total of 240 patients were evaluated, with half receiving pharmacogenomic-guided perioperative management. Significant differences were observed in IL-6 levels, opioid requirements and complication rates between genotypic groups. Pharmacogenomic-guided therapy effectively reduced postoperative complications and improved recovery, underscoring its potential for personalized surgical care.

Keywords

Pharmacogenomics, surgical stress response, abdominal surgery, CYP2D6, OPRM1, personalized medicine, perioperative care

Citation

Vyas et al. Bioinformation 21(11): 4005-4010 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.