Title

Effect of multiparametric MRI and ultrasound-guided biopsy for early prostate cancer detection: A prospective cohort study

Authors

Deepika Karunakaran¹, Holebasu Ballur², Archana Abarnadevi Karthikeyan³, Satya Sudhakara Bhat⁴, Kausalya Perumalsamy^5,* & Anannya Vaibhavi⁶

Affiliation

¹Department of Emergency Medicine, University Hospitals of Morecambe Bay, NHS Trust, United Kingdom; ²Department of Radio-Diagnosis, KLE Jagadguru Gangadhar Mahaswamigalu Moorsavirmath Medical College, Hubli, Karnataka, India; ³Department of HPB Surgery, Kings College Hospital, London, England, United Kingdom; ⁴Department of Trauma and Orthopaedics, Lancashire Teaching Hospitals NHS Foundation Trust, United Kingdom; ⁵Department of Pediatrics, Resident Medicla Officer, Kauvery Hospital, Tirunelveli, Tamil Nadu, India; ⁶Department of Physiology, RML hospital, Lucknow, Uttar Pradesh, India; *Corresponding author

Email

Deepika Karunakaran - E-mail: deepikakerh@gmail.com; Phone: +91 9842625355
Holebasu Ballur - E-mail: holebasusballur@gmail.com; Phone: +918095741090
Archana Abarnadevi Karthikeyan - E-mail:Archana.abarnadevikarthikeyan@nhs.net; Phone: 447776419488
Satya Sudharkara Bhat - E-mail: satyabhat97@gmail.com; Phone: +447438350972
Kausalya Perumalsamy - E-mail: kausalysamy100@gmail.com; Phone: +919488775661
Anannya Vaibhavi - E-mail: anannyaavs@gmail.com; Phone: +919599971912

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

It is essential to detect clinically significant prostate cancer (csPCa) in an early and precise manner. However, there are challenges given that the usual TRUS-guided biopsy may leave tumors undiagnosed, or only detect indolent disease. In this prospective cohort study of 200 patients, we compared the diagnostic accuracy of multiparametric MRI (mpMRI) with TRUS-guided biopsy. The study found better sensitivity (91% vs 68%) and specificity (76% vs 60%) than TRUS biopsy, and identified 22% more clinically significant cancers than TRUS biopsies. In addition, mpMRI showed better positive predictive value and negative predictive value than TRUS-guided biopsy; this suggests general advantage in diagnostic accuracy and performance for mpMRI. Data shows, there is support for mpMRI having improved efficacy as a method of detecting clinically significant prostate cancer early compared to TRUS-guided biopsy.

Keywords

Multiparametric MRI, USG biopsy, prostate cancer, magnetic resonance imaging

Citation

Karunakaran et al. Bioinformation 21(11): 4015-4019 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.