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Title

Evaluation of neurological outcomes after prolonged sedation among ICU patients: A prospective study in India

 

Authors

Kishore Sekar1,*, Hasan Saleem Manghi2 & Hadiya Shakil3

 

Affiliation

1Department of General Surgery, Queens Hospital, London, Romford, United Kingdom; 2Department of Intensive Care/Accidents and Emergency, Eterna Health, Sindh, Pakistan; 3Department of Accident & Emergency, Dr. Ziauddin Hospital, Sindh, Pakistan; *Corresponding author

 

Email

Kishore Sekar - E-mail: kishoresekar24533@gmail.com; Phone: +91 9442226262/+44 7404467227
Hasan Saleem Manghi - E-mail: hasanmanghi@gmail.com; Phone: +923213834045
Hadiya Shakil - E-mail: hadiyashakil@hotmail.com; Phone: +923322470559

 

Article Type

Research Article

 

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

 

Abstract

Extended sedation in intensive care settings can produce neurological problems. Hence, this prospective study analyzed the neurological recovery of patients receiving continuous sedation (> 72 hours). Neurological function was evaluated at the time of ICU discharge and at three months to assess for any residual cognitive or functional impairment. Most patients appeared to recover completely and achieve their baseline pre-morbid function although a small number had mild persistent cognitive impairment. The data suggest that with continued vigilance after prolonged sedation greater than 72 hours there are generally no significant long-term neurological implications, which can be useful to render safer sedation methods in critical care medicine.

 

Keywords

Sedation, intensive care unit, neurological outcomes, cognitive recovery, prospective study

 

Citation

Sekar et al. Bioinformation 21(11): 4072-4075 (2025)

 

Edited by

A Prashanth

 

ISSN

0973-2063

 

Publisher

Biomedical Informatics

 

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.