Title

Hematological and gastroprotective effects of Madhulai Manappagu syrup in indomethacin-induced gastric ulcer animal models

Authors

T. Manavalan¹, S Priyadharshini², V.Kalvimoorthi³, G. Senthilvel⁴, L. Gopi³, K.S Sridevi Sangeetha⁵ & M. Meenakshi Sundaram^2,*

Affiliation

¹Department of Pharmacology, Mayor Radhakrishnan College of Pharmacy, Cuddalore, India; ²Department of Paediatrics (Kuzhandhai Maruthuvam), National Institute of siddha, Chennai-Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India; ³Department of Pharmaceutics, Aadhi Bhagwan College of Pharmacy, Randam, Thiruvannamalai, Tamil Nadu, India; ⁴Department of Gunapadam, National Institute of siddha-Affiliated to The Tamil Nadu Dr. M.G.R. Medical University, Chennai, India; ⁵Department of Pharmacology, Faculty of Allied Health Science, Meenakshi Academy of Higher Education, Chennai, India; *Corresponding author

Email

T. Manavalan - E-mail: manavalan762000@gmail.com
S Priyadharshini - E-mail: spriyadharshini1221@gmail.com
V.Kalvimoorthi - E-mail: Kalvimoorthi@gmail.com
G. Senthilvel - E-mail: siddha.senthilvel@gmail.com
L. Gopi - E-mail: lgopipharma10@gmail.com
G.K Sridevi Sangeetha - E-mail: sangeethsb@gmail.com
M. Meenakshi Sundaram - E-mail: sundaram.m.m.nis@gov.in, Phone: +91 9444214582

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

Gastric ulcer is a major gastrointestinal disorder with high global prevalence. Madhulai Manappagu, a Siddha herbal syrup preparation, is traditionally prescribed for gastric ailments,is of interest to evaluate the gastroprotective and hematological effects of Madhulai Manappagu in indomethacin-induced gastric ulcer in Wistar albino rats. Hematological parameters including hemoglobin, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, packed cell volume, platelet count and serum iron were determined using standard protocols and for anti-ulcer evaluation, Madhulai Manappagu was given orally at 500 and 1000 mg/kg body weight. Treatment with Madhulai Manappagu significantly (p < 0.00001) and dose-dependently improved hematological indices and serum iron levels in ulcerated rats compared to positive control. Madhulai Manappagu demonstrates significant gastroprotective and hematological benefits in indomethacin-induced ulcerated rats, hence show its potential as a safe plant-based therapeutic option for gastric ulcer, particularly in bleeding-associated conditions.

Keywords

Gastric ulcer, hematological parameters, madhulai manappagu, ulcer index, siddha medicine

Citation

Manavalan et al. Bioinformation 21(11): 4102-4110 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.