Title
Salivary pH, uric acid and C - reactive protein in conventional versus chitosan-nanoparticle denture wearers
Authors
Chanchal Anand, Nivedita Dixit*, M Monika, Srashti Singh, Manisha Gaurav & Shyamli
Affiliation
Department of Prosthodontics and Crown & Bridge, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India; *Corresponding author
Chanchal Anand - E-mail: chanchal93anand@gmail.com
Nivedita Dixit - E-mail: nividixie@gmail.com
M Monika - E-mail: monicachaudhary08@gmail.com
Srashti Singh - E-mail: srashtisingh94@gmail.com
Manisha Gaurav - E-mail: manishagaurav22@gmail.com
Shyamli - E-mail: shyamli28jan@gmail.com
Article Type
Research Article
Date
Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025
Abstract
Edentulous patients wearing complete dentures often face poor denture hygiene and mucosal inflammation. Incorporating antimicrobial agents such as chitosan nanoparticles (CNPs) into dentures may improve the oral environment. In this study, salivary pH, uric acid and C-reactive protein (CRP) were compared between conventional dentures and CNP-incorporated dentures in edentulous patients. After one month of use, CNP dentures significantly increased salivary pH and uric acid while showing a non-significant decrease in CRP. Thus, we show that CNP incorporation enhances oral health by improving salivary parameters and reducing inflammatory responses.
Keywords
Chitosan nanoparticles, complete denture, saliva, pH, uric acid, C-reactive protein, biomarkers, inflammation
Citation
Anand et al. Bioinformation 21(11): 4111-4115 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
