Title
Detection of asymptomatic coronary artery disease among patients with type 2 diabetes mellitus using treadmill test
Authors
Gagan Gunjan1, Ritesh L Chauhan2, Pushpendra Singh Sengar3 & Madhur Sharma4,*
Affiliation
1Department of Medicine, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, 2Department of General Medicine, RD Gardi Medical College, Ujjain, Madhya Pradesh, India, 3Department of Medicine, Bundelkhand Medical College & Hospital, Sagar, Madhya Pradesh, India, 4Department of Gastroenterology, MMIMSR, Ambala, Haryana, India; *Corresponding author
Gagan Gunjan - E-mail: gagangunjan1@gmail.com
Ritesh L Chauhan - E-mail: chauhan.ritesh19@gmail.com
Pushpendra Singh Sengar - E-mail: sengarpraveen007@gmail.com
Madhur Sharma - E-mail: drmadhursharma@gmail.com
Article Type
Research Article
Date
Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025
Abstract
Type 2 diabetes mellitus (T2DM) is strongly associated with silent myocardial ischemia (SMI), an asymptomatic form of coronary artery disease (CAD) and making early detection vital to prevent cardiac events. Therefore, it is of interest to evaluate 75 asymptomatic T2DM patients (mean age 53.27 ± 9.22 years) using the treadmill test (TMT) with the Bruce protocol and compared clinical and biochemical parameters between TMT-positive and negative groups. TMT was positive in 20 patients (26.66%), who were significantly older and had longer diabetes duration, higher HbA1c, fasting and postprandial glucose levels and adverse lipid profiles compared to TMT-negative patients. Dyslipidemia, elevated triglycerides and LDL and reduced HDL were particularly prominent among TMT-positive individuals. Thus, we show that longer disease duration, poor glycemic control and dyslipidemia are strong predictors of asymptomatic CAD and TMT is a useful non-invasive tool for its early detection in T2DM patients.
Keywords
Type 2 diabetes mellitus, asymptomatic coronary artery disease, treadmill test, silent myocardial ischemia, HbA1c, dyslipidemia.
Citation
Gunjan et al. Bioinformation 21(11): 4128-4132 (2025)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
