Title
Adverse drug reaction (ADR) monitoring of antihypertensive drugs in a tertiary care setting: A prospective observational study
Authors
Mehre Darakhshan Mehdi1,*, Md Imran Mehdi2, Mehre Afshan Mehdi3, Md. Umar Abdullah4 & Zohra Jabeen5
Affiliation
1Department of Pharmacology, ESIC Medical College and Hospital, Bihta, Patna, Bihar, India; 2Department of Anaesthesia, Saroja Sitaram Sadar Hospital, Sheohar, Bihar, India; 3Department of Obstetrics and Gynaecology, Nalanda Medical College and Hospital, Patna, Bihar, India; 4Department of Surgery, Patna Medical College and Hospital, Patna, Bihar, India; 5Department of Obstetrics and Gynaecology, Saroja Sitaram Sadar Hospital, Sheohar, Bihar, India; *Corresponding author
Mehre Darakhshan Mehdi - E-mail: dr.m.d.mehdi@gmail.com
Md Imran Mehdi - E-mail: drimranmehdi@gmail.com
Mehre Afshan Mehdi - E-mail: dr.m.a.mehdi@gmail.com
Md. Umar Abdullah - E-mail: umru786@gmail.com
Zohra Jabeen - E-mail: zohramedico@gmail.com
Article Type
Research Article
Date
Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025
Abstract
Hypertension requires long-term therapy. However, antihypertensive drugs may cause adverse drug reactions (ADRs) affecting compliance and quality of life. This 12-month prospective observational study included 500 patients receiving at least one antihypertensive medication. A total of 95 ADRs (17.6%) were identified, most commonly due to calcium channel blockers and ACE inhibitors, with pedal edema, dry cough and dizziness being the frequent events. ADRs were significantly higher in patients on polypharmacy (p = 0.004) and most were classified as moderate and probable. Active pharmacovigilance is essential to improve safety and optimize hypertension management.
Keywords
Adverse drug reaction, pharmacovigilance, antihypertensive agents, hypertension, drug safety, naranjo algorithm
Citation
Mehdi et al. Bioinformation 21(11): 4133-4137 (2025)
Edited by
Vini Mehta
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
