Title

Managing medication-related osteonecrosis of jaw: a prospective observational study

Authors

Mahendra Kumar Dadarwal¹, Timbadiya Vijaykumar Mansukhbhai^2,*, Nishad Gawali³, Pradeep Kumar Dohare⁴, Sumit Bhatt⁵, Swati Kharat⁶ & Rashmi Laddha⁶

Affiliation

1Department of Oral Surgery, Rajasthan Dental College, Jaipur, Rajasthan, India; 2Department of Oral Pathology and Microbiology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India; 3Department of Public Health Dentistry, Hazaribag College of Dental Sciences and Hospitals, Hazaribagh, Jharkhand, India; ⁴Department of Community Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India; ⁵Department of Oral and Maxillofacial Surgery, Rajasthan Dental College and Hospital, Jaipur, Rajasthan, India; ⁶Department of Prosthodontics, Dr RR Kambe Dental College and Hospital, Akola, Maharashtra, India; *Corresponding author

Email

Mahendra Kumar Dadarwal - E-mail: drdadarwal143@gmai.com
Timbadiya Vijaykumar Mansukhbhai - E-mail: Vijay818nu@gmail.com
Nishad Gawali - E-mail: nishadgawali@gmail.com
Pradeep Kumar Dohare - E-mail: pkdohare424@gmail.com
Sumit Bhatt - E-mail: sumittbhatt22@gmail.com
Swati Kharat - E-mail: dr.swatiladdha@gmail.com
Rashmi Laddha - E-mail: drrashmirdaga@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) remains a significant clinical challenge due to its complex etiology and variable response to treatment. This prospective observational study evaluated the effectiveness of current management protocols in 130 patients receiving antiresorptive or antiangiogenic therapies. Patients were assessed clinically and radiographically and treated according to standardized stage-specific guidelines. Combined conservative and surgical interventions achieved better healing rates, symptom control, and improved quality of life over 12 months. These findings support ongoing refinement of stage-based MRONJ protocols to optimize therapeutic outcomes and patient care.

Keywords

Medication-related osteonecrosis of the jaw (MRONJ), antiresorptive therapy, management protocols, jaw osteonecrosis, conservative treatment, surgical intervention, bone healing

Citation

Dadarwal et al. Bioinformation 21(11): 4144-4147 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.