Title

Effect of platelet-rich fibrin in enhancing healing after impacted mandibular third molar extractions: A randomized controlled trial

Authors

Richa Bahadur¹, A Anshumali²*, Sajjad Salam³, Vishal Kulkarni⁴, D. Navin Kumar⁵, Vikram Karande⁶ & Anukriti Kumari⁷

Affiliation

¹Department of Dentistry, ESIC Medical College & Hospital, Namkum, Ranchi, Jharkhand, India; ²Department of Anaesthesia, ESIC Medical College & Hospital, Namkum, Ranchi, Jharkhand, India; ³Dental and Maxillofacial Services, Bahrain Defense Forces - Military Hospital, Bahrain; ⁴Department of Oral and Maxillofacial Surgery, Army Dental Centre Research and Referral, Delhi Cantt, India; ⁵Department of Periodontology, Madha Dental College, Chennai, Dr. MGR Medical University, Guindy, Chennai, Tamil Nadu, India; ⁶Department of Oral & Maxillofacial Surgery, D.Y. Patil Dental School, Lohegaon, Pune, Maharashtra, India; ⁷Department of Oral Medicine and Radiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India; *Corresponding author

Email

Richa Bahadur - E-mail: richabahadur5@gmail.com
Anshumali - E-mail: Dr.anshumalisinha@gmail.com
Sajjad Salam - E-mail: drsajjadsalam@gmail.com
Vishal Kulkarni - E-mail: vishalkulkarni2aug@rediffmail.com
D. Navin Kumar - E-mail: navindentistry@gmail.com
Vikram Karande - E-mail: drvikramkarande@gmail.com
Anukriti Kumari - E-mail: anukritishrma0@gmail.com

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

The effect of platelet-rich fibrin (PRF) in improving healing post-impacted mandibular third molar extractions is of interest. Hence, a randomized trial was conducted with 30 patients, comparing outcomes between those treated with PRF and those without. The results demonstrated that PRF significantly reduced pain and swelling and promoted better bone healing, particularly in the early postoperative period. Although benefits plateaued at 6 months, PRF remains a promising adjunct for enhancing recovery in oral surgery.

Keywords

Platelet-rich fibrin, third molar extraction, bone regeneration, postoperative healing, pain reduction

Citation

Bahadur et al. Bioinformation 21(11): 4167-4172 (2025)

Edited by

Ritik Kashwani

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.