Title

Analytical study on metabolic syndrome and psoriasis severity: A cross sectional study

Authors

Amirtha Varshine Navaneeta Krishnan¹, Achal Ganiga Lingaraj², Amir Kammoun³, Shravya Kanishka Mareboina³, Sebah Elsa John⁴, Joshua Chacko^5,* & Muhammed Nabeel Pullithodika⁶

Affiliation

¹Department of General Medicine, Stanley Medical College Hospital, Chennai, Tamil Nadu, India; ²Department of General Medicine, Mysore Medical College and Research Institute, Kuvempu, Mysore, Karnataka, India; ³Department of General Medicine, Sechenov University, Moskva, Russia; ⁴Department of General Medicine, General Hospital, Narayanapuram, Alappuzha, Kerala, India; ⁵Department of General Medicine, Swansea Bay University Health Board, Baglan, Port Talbot; ⁶Department of Dermatology, All India Institute of Medical Sciences, Bibinagar, Telangana, India; *Corresponding author

Email

Amirtha Varshine Navaneeta Krishnan - E-mail: varshine99@gmail.com; Phone: +91 9677405858
Achal Ganiga Lingaraj - E-mail: achalganiga@gmail.com; Phone: +91 94831 46494
Amir Kammoun - E-mail: Amir.kamoung@gmail.com; Phone: +7 916 303-15-41
Shravya Kanishka Mareboina - E-mail: shravyakanishka.mareboina@gmail.com; Phone: +7 969 042-56-85
Sebah Elsa John - E-mail: sabahelsa1598@gmail.com
Joshua Chacko - E-mail: joshuachacko53@gmail.com; Phone: +918792294344
Muhammed Nabeel Pullithodika - E-mail: muhammednabeelpt49@gmail.com; Phone: +91 75598 37914

Article Type

Research Article

Date

Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025

Abstract

Psoriasis is a chronic inflammatory skin disease increasingly linked to metabolic syndrome, yet the extent of this association remains unclear. This cross-sectional study examined the relationship between psoriasis severity and metabolic syndrome among 122 adults with chronic plaque psoriasis. Psoriasis Area and Severity Index (PASI) scores were significantly higher in patients with metabolic syndrome, indicating greater disease severity. Central obesity and dyslipidemia were the most prevalent metabolic factors associated with elevated PASI scores. Thus, we show the importance of routine metabolic screening in psoriasis patients to improve disease management and outcomes.

Keywords

Psoriasis, metabolic syndrome, psoriasis area and severity index (PASI) score, cross-sectional study, obesity, dyslipidemia, disease severity

Citation

Krishnan et al. Bioinformation 21(11): 4185-4188 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.