Title
Photobiomodulation in dentistry: Mechanisms, clinical applications and evidence-based guidelines
Authors
Lana Eltahir1,*, Moustafa Elgendy2, Gaya Ali3, Abrar Elamin4, Sarah Omer5 & Neerman Khazam6
Affiliation
1Department of Dental Surgery, Lana Eltahir, Sudan; 2Department of Dental Surgery, Moustafa Elgendy, Egypt; 3Department of Dental Surgery, Gaya Ali, Sudan; 4Department of Dental Surgery, Abrar Elamin, Sudan; 5Department of Dental Surgery, Sarah Omer, Libya; 6Department of Dental Surgery, Neerman Khazam, Libya; *Corresponding author
Lana Eltahir - E-mail: lana_eltahir@outlook.com
Moustafa Elgendy - E-mail: elgendysm@gmail.com
Gaya Ali - E-mail: gaya0092@gmail.com
Abrar Elamin - E-mail: abrar_elamin@hotmail.com
Sarah Omer - E-mail: sara.ibnouf@gmail.com
Neerman Khazam - E-mail: neermankhazam@gmail.com
Article Type
Review
Date
Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025
Abstract
Photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), utilizes red and near-infrared light to activate mitochondrial chromophores, thereby enhancing cellular activity, modulating inflammation and promoting tissue repair. Therefore, it is of interest to the mechanistic pathways of PBM, including mitochondrial stimulation, cytokine regulation and growth factor induction. Clinical evidence supports its efficacy in managing oral mucositis, temporomandibular disorders, periodontitis, postoperative endodontic pain, implant stability and orthodontic treatment outcomes.
Keywords
Photobiomodulation, low-level laser therapy, oral mucositis, temporomandibular disorders, periodontitis, endodontics, dental implants, orthodontics, laser therapy, PBM safety, pain management, tissue regeneration
Citation
Eltahir et al. Bioinformation 21(11): 4203-4206 (2025)
Edited by
Rashmi Daga
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
