Title
Arsenicum iodatum and arseicum album induces apoptosis and autophagy in glioblastoma multiforme
Authors
Ankit Pateriya1, Pratima Gupta2, Ashutosh Shrivastava1,*, Dhruv Varshney1, Sreyanko Sadhukhan3,4, Manendra Singh Tomar1, Arun Kumar Gupta5, Naibedya Chattopadhyay3,4 & Rohit Anthony Sinha2
Affiliation
1Center for Advance Research, Faculty of Medicine, King George’s Medical University, Lucknow-226003, Uttar Pradesh, India; 2Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow-226014, Uttar Pradesh, India; 3Division of Endocrinology and Centre for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India; 4Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, Uttar Pradesh, India; 5Homeopathic Drug Research Institute, Lucknow-226010, Uttar Pradesh, India; *Corresponding author
Ankit Pateriya - E-mail: ankitpateriyasr@kgmcindia.edu
Pratima Gupta - E-mail: pratimag@sgpgi.ac.in
Dhruv Varshney - E-mail: varshneydhruv99@gmail.com
Sreyanko Sadhukhan - E-mail: sreyanko.cdri21@acsir.res.in
Manendra Singh Tomar - E-mail: manendratomar16@kgmcindia.edu
Arun Kumar Gupta - E-mail: drgupta_hema@yahoo.co.in
Naibedya Chattopadhyay - E-mail: n_chattopadhyay@cdri.res.in
Rohit Anthony Sinha - E-mail: rasinha@sgpgi.ac.in
Ashutosh Shrivastava - E-mail: ashutoshshrivastava@kgmcindia.edu
Article Type
Research Article
Date
Received October 1, 2025; Revised November 15, 2025; Accepted November 15, 2025, Published November 15, 2025
Abstract
Glioblastoma multiforme (GBM) is a highly aggressive and treatment-resistant brain tumor, highlighting the need for novel therapeutic strategies. Therefore, it is of interest to investigate the anti-cancer effects of Arsenicum iodatum and Arsenicum album in U87 glioblastoma cells at 6C, 12C and 30C potencies. Both preparations induced apoptosis, confirmed by TUNEL along with the caspase-3 assays and triggered autophagy, evidenced by reduced p62 levels. Inhibition of autophagy enhanced cytotoxicity, indicating its protective role in GBM cells. Thus, we show that Arsenicum iodatum and Arsenicum album may serve as complementary candidates for GBM therapy, warranting further in vivo and mechanistic studies.
Keywords
Glioblastoma multiforme, apoptosis, autophagy, homeopathic drugs
Citation
Pateriya et al. Bioinformation 21(11): 4236-4240 (2025)
Edited by
P Kangueane
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
