Title

Developmental origin and clinical profile of siamese twins in a tertiary care setting

Authors

Archana Tiwari^1,*, Bindu Singh², Akshay Nigam³, Vishnu Kumar Gupta⁴ & Parul Nema⁵

Affiliation

¹Department of Anatomy, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh, India; ²Department of Anatomy, Baba Raghav Das Medical College, Gorakhpur, Uttar Pradesh, India; ³Department of Radiotherapy, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India; ⁴Department of Community Medicine, SRVS Medical College, Shivpuri, Madhya Pradesh, India; ⁵Department of Pathology, SRVS Medical College, Shivpuri, Madhya Pradesh, India; *Corresponding author

Email

Archana Tiwari - E-mail: drarchanatiwari15@gmail.com
Bindu Singh - E-mail: bindusingh10@gmail.com
Akshay Nigam - E-mail: drakshay.nigam@myyahoo.com
Vishnu Kumar Gupta - E-mail: vishnukgupta4@gmail.com
Parul Nema - E-mail: drparulnema@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Conjoined twins represent a rare outcome of incomplete monozygotic embryonic division and are associated with high perinatal morbidity and mortality. Therefore, it is of interest to analyze 12 cases managed at a tertiary care center, focusing on developmental origin, clinical classification and perinatal outcomes. Thoracopagus was the most frequent type (41.7%) and prenatal diagnosis was achieved in 75% of cases, primarily through ultrasonography. Cesarean delivery was performed in most cases and neonatal survival was 41.7%, with successful surgical separation in two instances. Early diagnosis, precise anatomical delineation and multidisciplinary planning are critical for optimizing outcomes in these complex cases.

Keywords

Conjoined twins, embryology, thoracopagus, prenatal diagnosis, neonatal outcome, surgical separation

Citation

Tiwari et al. Bioinformation 21(12): 4267-4270 (2025)

Edited by

Rashmi Daga

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.