Title

Retrospective analysis of seasonal patterns in atrial fibrillation incidence and temperature fluctuations

Authors

Pooja Saithya Pillarisetti¹, Karthik Mathiyalagan², Shanmukha Koppolu³, Sorabh Sharma⁴, Markondapatnaikuni Navya^5,* & Adithya Chandran⁶

Affiliation

¹Department of General Medicine, A.C.S.R Government Medical College Nellore Andhra Pradesh, India; ²Department of Trauma Surgery, King's College Hospital, London, United Kingdom; ³Department of Trauma and Orthopaedics, Barts NHS Trust, London, England, United Kingdom; ⁴Department of Internal Medicine, University of Arizona, Arizona, USA; ⁵Department of Emergency Medicine, Maharajah's Institute of Medical Sciences, Nellimarla, Vizianagaram andhra Pradesh, India; ⁶Department of Internal Medicine, Indira Gandhi Medical College and Research Institute, Pondicherry, India; *Corresponding author

Email

Pooja Saithya Pillarisetti - E-mail: ⁠pillarisettipoojasaithya@gmail.com; Phone: +91 7343856478
Karthik Mathiyalagan - E-mail: karthikmathi1998@gmail.com; Phone: +44 7799240945
Shanmukha Koppolu - E-mail: kshanmukha3@gmail.com; Phone: +44 7448304208
Sorabh Sharma -E-mail: Sorabh.gmch@gmail.com; Phone: 9084050291
Markondapatnaikuni Navya - E-mail: nav9390@gmail.com; Phone: +91 8341818717
Adithya Chandran - E-mail: adithyachandran12@gmail.com; Phone: +91 9629212794

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Atrial fibrillation (AF) remains the most common sustained arrhythmia contributing significantly to global morbidity and mortality. This retrospective study analyzed 126,389 adult patients across three tertiary hospitals from 2018 to 2022 to assess the seasonal variation in AF incidence with respect to ambient temperature. The incidence of AF was significantly higher during winter and early spring, showing an inverse correlation with mean daily temperature (r = −0.81, p < 0.001), particularly among elderly, hypertensive, and diabetic individuals. Cold-induced vasoconstriction, increased sympathetic tone, and inflammatory responses may underlie the seasonal rise in AF admissions. Recognizing these temperature-related variations can assist in identifying high-risk periods and guide preventive strategies to mitigate the burden of AF.

Keywords

Atrial fibrillation, seasonality, temperature, cardiovascular risk, retrospective analysis, winter onset

Citation

Pillarisetti et al. Bioinformation 21(12): 4293-4296 (2025)

Edited by

A Prashanth

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.