Title

Oral lesions in patients with systemic diseases: A hospital-based observational study

Authors

M.G. Dharmendra Kumar¹, Vijay Shekhar², Samir Mansuri³, Shiny Joseph⁴, Libni D. Angel⁵, Jagadish Prasad Rajguru⁶ & Heena Dixit⁷*

Affiliation

¹Department of Oral and Maxillofacial Surgery, C.K.S. Theja Dental College, Renigunta Road, Tirupati andhra Pradesh, India; ²Department of Dentistry, Nalanda Medical College Hospital, Agamkuan, Patna, Bihar, India; ³Consultant Oral and Maxillofacial Surgeon, Ahmedabad, Gujarat, India; ⁴Department of Periodontics, Al Azhar Dental College, Thodupuzha, Kerala, India; ⁵Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India; ⁶Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College & Hospital, Bhubaneswar, Odisha, India; ⁷Department of Medical Health Administration, Index Institute, Malwanchal University, Index City, Nemawar Road, Indore, Madhya Pradesh, India; *Corresponding author

Email

M.G. Dharmendra Kumar - E-mail: dr.dharmendramaxfax@gmail.com
Vijay Shekhar - E-mail: vjsspitzer@yahoo.in
Samir Mansuri - E-mail: samirmansuri202022@gmail.com
Shiny Joseph - E-mail: drshinyjoseph@rediffmail.com
Libni D. Angel - E-mail: libniangel2.ll@gmail.com
Jagadish Prasad Rajguru - E-mail: drgurumdsop@gmail.com
Heena Dixit - E-mail: drheenatiwari@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Systemic diseases frequently manifest through characteristic oral lesions, making the oral cavity an important indicator of underlying medical conditions. Therefore, it is of interest to assess the prevalence and patterns of oral lesions among patients with confirmed systemic diseases in a hospital-based population. Hence, a cross-sectional observational analysis of 500 adults was conducted, documenting demographic data, systemic diagnoses and clinically verified oral findings, which were evaluated using WHO criteria and analyzed statistically. The results demonstrated high frequencies of periodontal disease, candidiasis, glossitis, aphthous ulcers and lichenoid reactions, with distinct associations observed between specific lesions and conditions such as diabetes mellitus, hypertension, anemia, gastrointestinal disorders, autoimmune diseases and chronic kidney disease. These findings highlight the essential role of routine oral examination in the early detection and multidisciplinary management of systemic diseases.

Keywords

Oral manifestations, systemic diseases, oral lesions, hospital-based study, observational study

Citation

Kumar et al. Bioinformation 21(12): 4359-4362 (2025)

Edited by

Rashmi Daga

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.