Title

Immediate implant placement with and without platelet-rich fibrin and decalcified freeze-dried bone graft

Authors

Akriti Agrawal¹*, Abdullah M. Alwaisi², Awaiz Ahmed³, Azza A. Abushama⁴, Noor Yasir², Shahnaaz Sultana⁵ & Md Kafeel Ahmed⁶

Affiliation

¹Department of Periodontology and Implantology, Consultant, P.N. Singhdeo Dental Clinic, Sambalpur, Odisha, India; ²Department of Periodontology and Implantology, Gulf Medical University, Ajman, Aljurf 1, UAE; ³Department of Pediatric Dentistry, Consultant, Dr. Awaiz's Dental Planet, Bidar, Karnataka, India; ⁴Department of Preventive Dental Sciences (Periodontology) College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia; ⁵Department of Periodontology and Implantology, Al Badar Rural Dental College and Hospital, Kalaburagi, Karnataka, India; ⁶Department of Periodontology and Implantology, MNR Dental College and Hospital, Sangareddy, Hyderabad, Telangana, India; *Corresponding author

Email

Akriti Agrawal - E-mail: akriti.agrawal17@gmail.com
Abdullah M. Alwaisi - E-mail: drabdullahalwaisi@gmail.com
Awaiz Ahmed - E-mail: dr.awaizpedo@gmail.com
Azza A. Abushama - E-mail: a.abdulmahmoud@dau.edu.sa
Noor Yasir - E-mail: noorhabeeb2015@gmail.com
Shahnaaz Sultana- E-mail: drshahnaazsultana@gmail.com
Md Kafeel Ahmed - E-mail: drkafeelsohar@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

There is a high risk of vertical and horizontal bone resorption in the peri-implant gap following immediate implant placement after non-molar tooth extraction, which compromises implant stability, hard/soft tissue preservation, and esthetic outcomes. The present study was a randomized controlled clinical trial included 40 patients requiring a single non-molar tooth extraction and immediate implant placement. Patients were randomly allocated into two equal groups (n=20). In the Test group, the peri-implant gap was filled with a composite of PRF and DFDBA. In the Control group, no grafting material was placed. The primary outcome was vertical bone level (VBL) change at 6 months, measured on standardized radiographs. Secondary outcomes included horizontal bone thickness changes measured on CBCT, implant stability quotient (ISQ) at baseline and 3 months and Pink Esthetic Score (PES) at 6 months. Independent t-tests were used for statistical analysis (α=0.05). The adjunctive use of a composite PRF and DFDBA graft in immediate implant placement sockets significantly improves the preservation of peri-implant hard and soft tissues, enhances secondary implant stability and leads to superior esthetic outcomes compared to no grafting.

Keywords

Immediate implant placement, platelet-rich fibrin, bone grafting, DFDBA, implant stability, dental esthetics

Citation

Agrawal et al. Bioinformation 21(12): 4430-4434 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.