Title

Association between treatment outcomes and extent of chest X-ray involvement among pulmonary tuberculosis patients under RNTCP in North India: A prospective study

Authors

Mahesh Kumar Patidar^1,*, Rakesh Kumar Sisodia², Dhiresh Jaiswal³, Shushil Munjal⁴ & Deepak Nagar¹

Affiliation

¹Department of Respiratory Medicine, Government Medical College, Ratlam, Madhya Pradesh, India; ²Department of General Medicine, Government Medical College, Ratlam, Madhya Pradesh, India; ³Department of Respiratory Medicine, Government Medical College, Datia, Madhya Pradesh, India; ⁴Department of Respiratory Medicine, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi; *Corresponding author

Email

Mahesh Kumar Patidar - E-mail: dr.mahesh7patidar@gmail.com
Rakesh Kumar Sisodia - E-mail: dr.r.k.sisodia17@gmail.com
Dhiresh Jaiswal - E-mail: jaiswaldhireshp07@gmail.com
Shushil Munjal - E-mail: drmunjal2004@yahoo.co.in
Deepak Nagar - E-mail: drdeepaknagar110@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Tuberculosis (TB) remains one of the leading causes of morbidity and mortality in India, with pulmonary involvement contributing significantly to disease burden and transmission. Hence, this prospective observational study enrolled new and previously treated sputum smear-positive patients from the NITRD DOTS area 1st September 2019 to 31st October 2019. All participants received a 6-month drug-sensitive TB regimen (2 months of HRZE followed by 4 months of HRE) to assess treatment outcomes at the end of six months. The study also analyzed whether the extent of chest X-ray involvement was associated with treatment outcome. Data shows that both the extent of chest X-ray involvement and the presence of cavities on chest X-ray were found to be significantly associated with unsuccessful treatment outcomes.

Keywords

Pulmonary Tuberculosis, drug-sensitive, chest X-ray.

Citation

Patidar et al. Bioinformation 21(12): 4448-4452 (2025)

Edited by

Vini Mehta

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.