Title
Early continuous positive airway pressure versus surfactant therapy in preterm neonates with respiratory distress
Authors
Priyasha Tripathi*, Anshika Taiwade, Deepak K Uikey & Neeti Agarwal
Affiliation
Department of pediatrics, Atal Bihari Vajpayee govt medical College, Vidisha, Madhya Pradesh, India; *Corresponding author
Priyasha Tripathi - E-mail: drpriyasha21@gmail.com
Anshika Taiwade - E-mail: anshika22.taiwade@gmail.com
Deepak K Uikey - E-mail: drkumardeepak0@gmail.com
Neeti Agarwal - E-mail: agarwalneeti7@gmail.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Respiratory Distress Syndrome (RDS) remains a major cause of morbidity and mortality in preterm neonates, particularly in resource-limited Level 2 Special Newborn Care Units. Therefore, it is of interest to analyse outcomes of 308 preterm neonates treated with early Continuous Positive Airway Pressure (CPAP) or combined CPAP–surfactant therapy across three gestational age groups. Survival was highest with CPAP alone in moderate and late preterm neonates (31–36 weeks), reaching 84.4%–87.3%. Extremely preterm neonates (27–30 weeks) showed improved outcomes with early selective surfactant plus CPAP, though mortality remained higher due to pulmonary hemorrhage and sepsis. Early CPAP is highly effective for 31–36-week neonates, while extremely preterm infants benefit most from combined CPAP–surfactant therapy.
Keywords
Preterm, CPAP, surfactant therapy, neonatal respiratory distress, Level 2 SNCU, respiratory distress syndrome.
Citation
Tripathi et al. Bioinformation 21(12): 4575-4579 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
