Title

Correlation of troponin I and CK-MB with COVID-19 severity in seriously ill patients: A retrospective analysis from medical records

Authors

Jyoti Shukla¹*, Ritesh Yadav², Divyansh Gupta², Pankaj Sharma³ & Nishant Singh Verma³

Affiliation

¹Department of Biochemistry, Shrimant Rajmata Vijayaraje Scindia Medical College Shivpuri, Madhya Pradesh, India; ²Department of General Medicine, Shrimant Rajmata Vijayaraje Scindia Medical College Shivpuri, Madhya Pradesh, India; ³Department of Orthopaedics, Shrimant Rajmata Vijayaraje Scindia Medical College, Shivpuri, Madhya Pradesh, India; *Corresponding author

Email

Jyoti Shukla - E-mail: jsa2biochem@gmail.com
Ritesh Yadav - E-mail: dr.ritesh_123@yahoo.co.in
Divyansh Gupta - E-mail: drdivyansh2008@gmail.com
Pankaj Sharma - E-mail: doctor.pankaj2007@gmail.com
Nishant Singh Verma - E-mail: dr.nishantsinghverma@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

COVID-19 is frequently associated with cardiovascular complications, with cardiac troponin I (cTnI) and CK-MB serving as markers of myocardial injury. Therefore, it is of interest to analyse of medical records from 300 PCR-confirmed COVID-19 patients admitted to High Dependency Unit (HDU) and Intensive Care Unit (ICU) during the second wave (2020-2021), biomarker levels at admission were correlated with disease severity. All patients included were seriously ill but survived. Severe cases had significantly higher cTnI and CK-MB levels (p < 0.001). These biomarkers provide important early prognostic information For the purpose of risk assessment and therapeutic treatment of COVID-19.

Keywords

COVID-19, SARS-CoV-2, Myocardial Injury, Troponin I, CK-MB, Prognosis, Severity.

Citation

Shukla et al. Bioinformation 21(12): 4585-4588 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.