Title
Current perspectives on bioceramic sealers in endodontics: A review
Authors
Lakshmi Durga Alekhya Donipudi1,*, Farzana Shereen2, Venkata Soundarya Kolaparthi3, Sana Fadlalla4, Pranitha Presingu5 & Huma Tahir6
Affiliation
1Department of Dental surgery, GSL Dental College & Hospital, Rajamahendravaram, Andhra Pradesh, India; 2Department of Dental Surgery, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda District, Telangana, India; 3Department of Public Health, Nova Southeastern University, Fort Lauderdale, FL, USA; 4Department of Dental Surgery, University of Khartoum, Faculty of Dentistry, Khartoum, Sudan; 5Department of Health Informatics, Grand Valley State University, Allendale, MI, USA; 6Department of Dental Surgery, University College of Medicine and Dentistry, Lahore, Pakistan; *Corresponding author
Lakshmi Durga Alekhya Donipudi - E-mail:
donipudi.alekhya111@gmail.com
Farzana Shereen - E-mail: shereen4611@gmail.com
Venkata Soundarya Kolaparthi - E-mail: Venkata.ks35@gmail.com
Sana Fadlalla - E-mail: sanafadlall57@gmail.com
Pranitha Presingu - E-mail: presingupranitha.usa@gmail.com
Huma Tahir - E-mail: humatahir50@gmail.com
Article Type
Review
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Bioceramic sealers, particularly calcium silicate-based formulations, have transformed endodontic therapy through superior biocompatibility, sealing and regenerative potential. Their chemical and mechanical interaction with dentin enhances long-term treatment outcomes. Therefore, it is of interest to summarize recent developments in their composition, mechanisms of action, classification, clinical applications and retreatment challenges, noting limitations such as retrievability, handling and cost. Emerging innovations, including nanotechnology and enhanced material rheology, may enhance clinical performance, with long-term clinical studies needed to validate their role in regenerative endodontics.
Keywords
Bioceramic sealers, Calcium silicate, endodontics, regenerative dentistry, nanotechnology, Zirconia and sealing ability
Citation
Donipudi et al. Bioinformation 21(12): 4599-4604 (2025)
Edited by
Rashmi Daga
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
