Title

Effect of I-PRF and alloplastic bone material in periodontal osseous defects - A case series

Authors

Kriti Agarwal¹, Kanika Agarwal², Jaideep Mahendra^3,*, Roshini Govindarajan⁴, Sajid.T.Hussain⁵ & Muskan Bedi⁶

Affiliation

¹Department of Periodontology, Santosh Dental College, Ghaziabad, Uttar Pradesh, India; ²Private Practitioner, Prayagraj, Uttar Pradesh, India; ³Department of Periodontics, Director of Postgraduate studies, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; ⁴Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India; ⁵Department of Periodontology and Implantology, Bharath University, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India; ⁶Department of Surgery, Sree Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India; *Corresponding author

Email

Kriti Agarwal - E-mail: drkritimds@gmail.com
Kanika Agarwal - E-mail: kanikamds@gmail.com
Jaideep Mahendra - E-mail: drjaideep.perio@madch.edu.in
Roshini Govindarajan - E-mail: roshinigkh24@gmail.com
Sajid T Hussain - E-mail: sajid2000@gmail.com
Muskan Bedi - E-mail: bedimuskan@gmail.com

Article Type

Views

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Periodontal regeneration in patients with chronic periodontitis remains a clinical challenge due to limited predictability of current regenerative materials and techniques. This case series was conducted on 10 patients diagnosed with moderate to advanced chronic periodontitis. Participants received i-PRF with Hydroxyapatite bone graft. Clinical parameters and radiographic bone defect depth were measured at baseline and after 6 months. Following surgical intervention, patients exhibited greater reductions in PPD, gains in CAL and increased bone fill suggesting that i-PRF may enhance periodontal regeneration when used in conjunction with alloplastic bone grafts.

Keywords

Chronic periodontitis, Hydroxyapatite, Intraosseous defect, i-PRF, periodontal regeneration

Citation

Agarwal et al. Bioinformation 21(12): 4634-4637 (2025)

Edited by

P Kangueane

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.