Title
New frontiers in oral sub-mucous fibrosis: The promise of collagen-based interventions
Authors
Khushbu Lamba1*, V. Raj Kumar1, Priya Yadav2, Rashika Jauhari3, Sagar R. Dixit4 & Aditi D. Mugalikar4
Affiliation
1Department of Oral and Maxillofacial Surgery, Jaipur Dental College, Jaipur, Rajasthan, India; 2Department of Periodontics, ESIC Dental College and hospital, Rohini, Delhi, India; 3Department of Conservative Dentistry and Endodontics, Jaipur Dental College, Jaipur, Rajasthan, India; 4Department of Oral and Maxillofacial Surgery, YMT Dental College and hospital, Kharghar, Navi Mumbai, India; *Corresponding author
Khushbu Lamba - E-mail: drkhushbu1555@gmail.com
V. Raj Kumar - E-mail: drraj.drraj@gmail.com
Priya Yadav - E-mail: drpriyayadav1994@gmail.com
Rashika Jauhari - E-mail: jauharirashika23@gmail.com
Sagar R. Dixit - E-mail: sagarrdixit97@gmail.com
Aditi D. Mugalikar - E-mail: mugalikaraditi@gmail.com
Article Type
Review
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Oral Sub-mucous Fibrosis (OSMF) is a chronic, progressive and potentially malignant disorder characterized by inflammation and fibrosis of the oral mucosa, often leading to significant morbidity and impaired quality of life. The pathogenesis of OSMF is strongly associated with abnormal collagen metabolism, resulting in excessive deposition and reduced degradation of collagen fibres. Traditional therapeutic modalities have shown limited success in reversing the fibrotic changes, underscoring the need for novel treatment approaches. Therefore, it is of interest to explore the emerging role of collagen-based interventions including modulation therapies, enzymatic degradation, and regenerative techniques) which target key molecular pathways to improve functional outcomes and arrest disease progression. The potential of combining collagen- based approaches with regenerative and personalized medicine in the effective management of OSMF is also promising.
Keywords
Oral Sub-mucous Fibrosis, collagen, fibrosis management, collagen modulation.
Citation
Lamba et al. Bioinformation 21(12): 4692-4696 (2025)
Edited by
Rashmi Daga
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
