Title

Assessment of chronic liver disease using shear wave elastography: Correlation with serum markers

Authors

Soumik Pal, Rajeev Kumar Ranjan*, Suresh Kumar Toppo, Mohd Ismail, Harish Shivprasad Gupta, Sonali Priyadarsini Reddy & Md Shahrukh Ansari

Affiliation

Department of Radio-diagnosis, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; *Corresponding author

Email

Soumik Pal - E-mail: soumikpalcmc@gmail.com
Rajeev Kumar Ranjan - E-mail: drrkranjanmd@gmail.com
Suresh Kumar Toppo - E-mail: rddrsuresh2205@gmail.com

Mohd Ismail - E-mail: mohdismail.ismail88@gmail.com
Harish Shivprasad Gupta - E-mail: harishgupta000098@gmail.com
Sonali Priyadarsini Reddy - E-mail: Sonalipriyadarsinireddy20@gmail.com
Md Shahrukh Ansari - E-mail: mshahrukh066@gmail.com

Article Type

Research Article

Date

Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025

Abstract

Chronic liver disease requires accurate fibrosis assessment, with non-invasive tools gaining importance over biopsy. Hence, this cross-sectional study evaluated liver fibrosis in 122 CLD patients using shear wave elastography (SWE) and correlated findings with serum markers. SWE showed strong correlation with APRI (r=0.70) and platelet count (r=-0.70), and moderate correlations with AST and FIB-4. Optimal SWE cutoffs were 9.2 kPa for significant fibrosis and 15.38 kPa for cirrhosis, with excellent diagnostic accuracy (AUROC=0.99). SWE combined with serum markers—especially APRI—provides a reliable, non-invasive alternative for fibrosis assessment in CLD patients.

Keywords

Chronic liver disease, shear wave elastography, liver fibrosis, serum markers, APRI, FIB-4, non-invasive assessment

Citation

Pal et al. Bioinformation 21(12): 4772-4776 (2025)

Edited by

Hiroj Bagde

ISSN

0973-2063

Publisher

Biomedical Informatics

License

This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.