Title
Transcranial ultrasound as a diagnostic tool for hypoxic-ischemic encephalopathy in preterm neonates: A cross-sectional study
Authors
Riya Agarwal, Nisha Rai*, Rajeev Kumar Ranjan, Suresh Kumar Toppo, Anima Ranjni Xalxo, Manisha Oraon, Harish S Gupta & Md Shahrukh Ansari
Affiliation
Department of Radio-diagnosis, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; *Corresponding author
Riya Agarwal - E-mail: riyarmg@gmail.com
Nisha Rai - E-mail: nisha_zandels@yahoo.com
Rajeev Kumar Ranjan - E-mail: drrkranjanmd@gmail.com
Suresh Kumar Toppo - E-mail: rddrsuresh2205@gmail.com
Anima Ranjni Xalxo - E-mail: dr.animaxalxo@gmail.com
Manisha Oraon - E-mail: oraonmanisha3007@gmail.com
Harish S Gupta - E-mail: harishgupta000098@gmail.com
Md Shahrukh Ansar - E-mail: mshahrukh066@gmail.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in preterm neonates, necessitating early and accurate diagnosis. Therefore, it is of interest to evaluated the diagnostic accuracy of transcranial ultrasound (TUS) in 168 preterm neonates with clinical features of HIE. Significant ultrasound findings—such as intraventricular hemorrhage, ventriculomegaly, multicystic leukomalacia and abnormal Doppler indices—showed strong correlations with severe SARNAT stages. The combined parameters demonstrated high diagnostic accuracy, with a sensitivity of 85.7% and specificity of 82.4%. TUS proves to be an effective, accessible tool for early detection and prognostication of HIE in preterm neonates.
Keywords
Hypoxic-ischemic encephalopathy, preterm neonates, transcranial ultrasound, diagnostic accuracy, neurosonography.
Citation
Agarwal et al. Bioinformation 21(12): 4785-4790 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
