Title
D-dimer levels in acute exacerbation of asthma among children: A correlation study
Authors
Pragya Pragya1, Prateek Pandey2, Ankita Dinkar1, Fahad Naaz1, Ashutosh Kumar1 & Partha Kumar Chaudhuri1*
Affiliation
1Department of Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; 2Department of Paediatrics, Sheikh Bhikhari Medical College and Hospital, Hazaribagh, Jharkhand, India; *Corresponding author
Pragya Pragya - E-mail: pragya0271@gmail.com
Prateek Pandey - E-mail:
prateekpandey93@gmail.com
Ankita Dinkar - E-mail: doc.ankita002@gmail.com
Fahad Naaz - E-mail: alisanaaz786@gmail.com
Ashutosh Kumar - E-mail: drashuanshul@gmail.com
Partha Kumar Chaudhuri - E-mail: pchaudhuri73@yahoo.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Asthma exacerbations in children may involve systemic coagulation changes reflected by elevated D-dimer levels. Therefore, it is of interest to evaluate 50 children aged 2-15 years to assess the correlation between D-dimer levels and acute exacerbation severity. D-dimer positivity increased significantly with severity-from 9.5% (mild) to 45.5% (moderate) and 71.4% (severe) (p=0.004). Positive D-dimer results were also strongly associated with longer hospital stays (p<0.001). Thus, we show that D-dimer is a valuable biomarker for assessing exacerbation severity and predicting clinical outcomes in pediatric asthma.
Keywords
D-dimer, asthma exacerbation, children, coagulation abnormalities, biomarker, pulmonary score
Citation
Pragya et al. Bioinformation 21(12): 4791-4795 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
