Title
Ultrasonography and sonoelastography in cervical lymph node differentiation: A cross-sectional study
Authors
Harish Shivprasad Gupta*, Suresh Kumar Toppo, Rajeev Kumar Ranjan, Anima Ranjni Xalxo, Nisha Rai, Soumik Pal, Riya Agarwal & Mohd Ismail
Affiliation
Department of Radio-diagnosis, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; *Corresponding author
Harish Shivprasad Gupta - E-mail:
harishgupta000098@gmail.com
Suresh Kumar Toppo - E-mail: rddrsuresh2205@gmail.com
Rajeev Kumar Ranjan - E-mail: drrkranjanmd@gmail.com
Anima Ranjni Xalxo - E-mail: dr.animaxalxo@gmail.com
Nisha Rai - E-mail: nisha_zandels@yahoo.com
Soumik Pal - E-mail: soumikpalcmc@gmail.com
Riya Agarwal - E-mail: riyarmg@gmail.com
Mohd Ismail - E-mail: mohdismail.ismail88@gmail.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Cervical lymphadenopathy poses a diagnostic challenge, particularly in distinguishing benign from malignant lymph nodes non-invasively. Therefore, it is of interest to evaluate the diagnostic utility of B-mode ultrasonography, color Doppler, strain elastography and shear wave elastography in 100 patients at a tertiary center in East India. Histopathology served as the reference standard to determine sensitivity, specificity and AUC for each modality. Shear wave elastography, especially perinodal rim stiffness, showed the highest individual accuracy, while the combined B-mode–Doppler–SWE approach demonstrated 94% overall accuracy. Thus, we show that integrating shear wave elastography with conventional ultrasonography significantly enhances differentiation of benign and malignant cervical lymph nodes.
Keywords
Cervical lymphadenopathy, ultrasonography, sonoelastography, shear wave elastography, strain elastography, diagnostic accuracy
Citation
Gupta et al. Bioinformation 21(12): 4862-4868 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
