Title
Linking elastographic evaluation benign and malignant liver lesion with histopathological data
Authors
Mohd Ismail, Anima Ranjni Xalxo*, Rajeev Kumar Ranjan, Suresh Kumar Toppo, Soumik Pal, Harish S.Gupta, Manisha Oraon & Sonali Priyadarsini Reddy
Affiliation
Department of Radio-diagnosis, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India; *Corresponding author
Mohd Ismail - E-mail:
mohdismail.ismail88@gmail.com
Anima Ranjni Xalxo - E-mail: dr.animaxalxo@gmail.com
Rajeev Kumar Ranjan - E-mail: drrkranjanmd@gmail.com
Article Type
Research Article
Date
Received November 15, 2025; Revised December 15, 2025; Accepted December 15, 2025, Published December 15, 2025
Abstract
Differentiating benign from malignant focal liver lesions remains a significant diagnostic challenge with conventional imaging modalities. Acoustic Radiation Force Impulse (ARFI) elastography offers a non-invasive approach by quantitatively measuring tissue stiffness through shear wave velocity (SWV). ARFI elastography findings were compared with histopathology to assess diagnostic accuracy among 124 patients with focal liver lesions. Malignant lesions demonstrated significantly higher SWV values than benign lesions and a cutoff of 1.96 m/s achieved excellent sensitivity, specificity and overall accuracy. ARFI elastography is a highly reliable and superior adjunct to conventional ultrasound for non-invasive differentiation of benign and malignant liver lesions.
Keywords
ARFI elastography, liver lesions, tissue stiffness, ultrasound, histopathological correlation, diagnostic accuracy
Citation
Ismail et al. Bioinformation 21(12): 4885-4889 (2025)
Edited by
Hiroj Bagde
ISSN
0973-2063
Publisher
License
This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. This is distributed under the terms of the Creative Commons Attribution License.
